24-Hour Emergency Room in Plano, TX

Expert emergency care. Board-certified ER physicians onsite 24/7. Advanced diagnostics and treatment. CT scans, X-rays, on-site labs, IV medications, stitches, fracture care, chest pain, abdominal pain, migraine treatment, and pediatric emergency care.
Online appointment is optional. Walk-ins are always welcome. If you are experiencing a life-threatening emergency, call 911.
What our patients say
“The staff is very friendly. I’ll stop by to grab a face mask and was met with pleasure and smiles. Very welcoming I will be back for Care.
“Absolutely amazing staff! In and Out with a smile! If you or anyone has any emergency services, trust me this is the place to come to!
“I had a earwax situation going on and they was able to help me relieve it immediately. the staff was also very friendly
Visit our Preston, Plano ER

“When patients walk into SignatureCare Emergency Center’s emergency room, they are often facing some of the most stressful moments of their lives. Our team is committed to providing prompt medical care, clear communication, and compassionate support every step of the way.”

“Every patient who walks through our doors deserves to feel heard, respected, and cared for. Our team at SignatureCare Emergency Center works around the clock to deliver expert emergency treatment while helping patients and their families find reassurance during difficult times.”

“Emergency care is about more than treating an illness or injury; it is about being there when our patients need help most. SignatureCare Emergency Center’s goal is to provide timely, high-quality medical attention with the compassion and dignity every patient deserves.”
Why Should You Choose SignatureCare Emergency Center?
We are nationally accredited, open 24/7, and trusted by patients for delivering exceptional emergency care. Our experienced physicians are dedicated to providing high-quality treatment in a comfortable, compassionate environment.

Not sure whether to visit an ER or an urgent care clinic?
Visit SignatureCare Emergency Center in Plano for illnesses or injuries that may require advanced imaging, diagnostic testing, IV medications, or prompt evaluation by an experienced emergency physician.
Still unsure? Call us anytime at 469-246-3446, and our team will help guide you and answer your questions.
Choose ER care for:
Urgent care may be better for:
Still not sure? Call us now at 469-246-3446, and our team can help guide you.
When you arrive at our ER
From walk-in to discharge — here's what happens. No long wait in a crowded waiting room. Average time from walk in to discharge is under 90 minutes for most patients.
Walk in
A nurse greets you within minutes of your arrival.
Quick triage
Your vitals taken and concerns addressed.
See a doctor
Board-certified ER physician at your bedside. CT, X-ray, or labs start immediately if needed.
Treat & discharge
Clear plan, prescriptions sent to your pharmacy, and a follow-up call the next day.
Inside our Preston, Plano ER
- Multi-slice CT
- Digital X-ray
- Ultrasound
- COLA-certified lab onsite
- Pediatric-friendly rooms
- Welcoming lobby





Insurance and Billing Questions?
SignatureCare Emergency Center on Preston Road, Plano, TX, is a licensed freestanding emergency room, and ER billing differs from urgent care billing. Our team is available to help you understand your insurance benefits, coverage details, and what to expect during your visit. We accept most major national insurance plans, including Workers’ Compensation. If you have questions about your specific coverage, please contact our Plano facility at 469-246-3446 for assistance. We are open 24/7 for your convenience.
If you are experiencing a serious or life-threatening emergency, please call 911 or go to the nearest emergency room immediately.
Frequently Asked Questions
We're open. Walk in anytime.
No appointment needed. Board-certified ER physicians available 24/7 at our Preston, Plano Emergency Room.